Rolling out DNA nanostructures in vivo: Fig. 1.

DNA nanostructures synthesized in vivo

Like natural diamonds, synthetic diamonds can be produced in a variety of grades, depending on growth conditions. High growth rates can be realized with chemical vapor deposition, but the diamond produced is often not clear because of nitrogen deposits that render the crystals absorptive over the infrared-toultraviolet spectrum, resulting in crystals that appear gray or brown. To reduce absorpt...

In vivo cloning of artificial DNA nanostructures.

Mimicking nature is both a key goal and a difficult challenge for the scientific enterprise. DNA, well known as the genetic-information carrier in nature, can be replicated efficiently in living cells. Today, despite the dramatic evolution of DNA nanotechnology, a versatile method that replicates artificial DNA nanostructures with complex secondary structures remains an appealing target. Previo...

Leukocyte Rolling In Vivo

The influence of platelet-vessel wall interactions on leukocyte rolling was investigated in rabbit mesenteric venules (diameter, 21-40 gm) using intravital videomicroscopy. Puncture of the wall with glass micropipettes (tip, 6-8 ,um) evoked the formation of a thrombus in all venules. In most vessels, emboli were produced as well. The rolling of leukocytes (i.e., their movement along the vessel ...

A method to study in vivo stability of DNA nanostructures☆

DNA nanostructures are rationally designed, synthetic, nanoscale assemblies obtained from one or more DNA sequences by their self-assembly. Due to the molecularly programmable as well as modular nature of DNA, such designer DNA architectures have great potential for in cellulo and in vivo applications. However, demonstrations of functionality in living systems necessitates a method to assess th...

Fig. 1